منابع مشابه
Designed IgM from glycoengineering.
Among the immunoglobulins, the IgGs have received the lion’s share of attention and dominate the monoclonal antibodies (mAbs) that are US Food and Drug Administrationapproved or are in research pipelines leading to the clinic. Whereas IgG is relatively easy to produce and purify and a number of host expression systems have been developed for that isotype, interest in the utility of other isotyp...
متن کاملExpression and glycoengineering of functionally active heteromultimeric IgM in plants.
IgM antibodies are an important player of the human's innate defense mechanisms and increasingly have gained interest as therapeutics. Although the expression of IgM antibodies in mammalian cell culture is established, this approach remains costly and alternative methods have not been developed yet. Plants have a proven record for the production of therapeutically relevant recombinant proteins....
متن کاملGlycoengineering of yeasts from the perspective of glycosylation efficiency.
N-linked glycosylation of proteins is one of the most common posttranslational modifications. N-glycan structures and N-glycosylation efficiency are crucial parameters in the production of N-glycosylated proteins. Yeast cells can be seen as an attractive production host for therapeutic glycoproteins and pioneering work of glycoengineering was performed in Pichia pastoris, realizing yeast strain...
متن کاملModulation of cellular adhesion by glycoengineering.
Aberrant glycosylation of lipid and protein molecules on cellular surfaces is responsible for many of the pathophysiological events in tumor progression and metastasis. Sialic acids in particular, are overexpressed on the glycocalyx of malignant tumor cells and sialic acid-mediated cell adhesion is required for metastasis. We report here that replacement of sialic acids on cell surfaces with fl...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2014
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1404904111